SACCHARIN METABOLISM AND TUMORIGENICITY

被引：31

作者：

SWEATMAN, TW

RENWICK, AG

机构：

[1] Clinical Pharmacology Group, University of Southampton, Medical and Biological Sciences Building

来源：

SCIENCE | 1979年 / 205卷 / 4410期

关键词：

D O I：

10.1126/science.472722

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exposure of male Charles River CDI rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo. No metabolites (< 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.

引用

页码：1019 / 1020

页数：2

共 11 条

[1] FATE OF [SACCHARIN-C-14] IN MAN, RAT AND RABBIT AND OF 2-SULFAMOYL[C-14]BENZOIC ACID IN RAT [J].