共 11 条
[11]
1978, SACCHARIN TECHNICAL
SACCHARIN METABOLISM AND TUMORIGENICITY
被引：31
作者：
SWEATMAN, TW
RENWICK, AG
机构：
[1] Clinical Pharmacology Group, University of Southampton, Medical and Biological Sciences Building
来源：
关键词：
D O I：
10.1126/science.472722
中图分类号：
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号：
07 ;
0710 ;
09 ;
摘要：
Exposure of male Charles River CDI rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo. No metabolites (< 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.
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页码：1019 / 1020
页数：2
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