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N-ACYLETHANOLAMINE ACCUMULATION IN INFARCTED MYOCARDIUM

被引：142
作者：
EPPS, DE
SCHMID, PC
NATARAJAN, V
SCHMID, HHO
机构：
[1] The Hormel Institute, University of Minnesota, Austin
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期
关键词：
D O I：
10.1016/0006-291X(79)91281-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long-chain N-acylethanolamines were found at levels of 400-500 nmol per g tissue in the infarcted areas of canine myocardium 24 hours after coronary artery ligation. Peripheral infarct areas also contained substantial amounts (200 nmol/g) while apparently normal heart muscle contained very little (< 10 nmol/g). The amide linked fatty acids were mainly 16:0, 18:0, 18:1 and 18:2. Because of its anti-inflammatory activity, N-acylethanolamine may exert beneficial effects in the infarcted area and may be produced as a response to ischemic injury. © 1979.
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页码：628 / 633
页数：6
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