AN IMPROVED METHOD FOR THE INTRODUCTION OF CARBON-CARBON TRIPLE BOND AT C-13 IN PG SYNTHESIS

被引：4

作者：

NARITA, S ^{[1
]}

TAKAHASHI, A ^{[1
]}

SATO, H ^{[1
]}

AOKI, T ^{[1
]}

YAMADA, S ^{[1
]}

SHIBASAKI, M ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 28期

关键词：

D O I：

10.1016/0040-4039(92)88095-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the introduction of carbon-carbon triple bond at C-13 in PG synthesis is described. The efficient aldol reaction of aldehydes has been achieved by using alpha-chloro enolate anions derived from 1-bromo-1-chloro ketones, giving alpha-chloro enones after dehydration in good yields, the precursor of the acetylenic alcohols.

引用

页码：4041 / 4044

页数：4

共 12 条

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[10] A NEW METHOD FOR THE INTRODUCTION OF CARBON CARBON TRIPLE BOND AT C-13 IN PG SYNTHESIS - A STEREOCONTROLLED SYNTHESIS OF ZK-96-480 [J].

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