5'-5'-TETHERED OLIGONUCLEOTIDES VIA NUCLEIC BASES - A POTENTIAL NEW SET OF COMPOUNDS FOR ALTERNATE STRAND TRIPLE-HELIX FORMATION

被引：19

作者：

ASSELINE, U ^{[1
]}

THUONG, NT ^{[1
]}

机构：

[1] CNRS,CTR BIOPHYS MOLEC,F-45071 ORLEANS 2,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 29期

关键词：

5'-5'-BRIDGED OLIGODEOXYRIBONUCLEOTIDES; OPPOSITE POLARITIES; TRIPLE-HELIX;

D O I：

10.1016/S0040-4039(00)77068-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid-phase synthesis of 5'-5'-linked oligonucleotides tethered via nucleic bases and with opposite polarities has been performed using a modified dinucleoside bearing a phosphoramidite group at the 3'-position of one nucleoside and a dimethoxytrityl group at the 3'-position of the second nucleoside.

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页码：5221 / 5224

页数：4

相关论文

共 15 条

[1]

[Anonymous], UNPUB

[2] OLIGONUCLEOTIDES TETHERED VIA NUCLEIC BASES - A POTENTIAL NEW SET OF COMPOUNDS FOR ALTERNATE STRAND TRIPLE-HELIX FORMATION [J].

ASSELINE, U ;

THUONG, NT .

TETRAHEDRON LETTERS, 1993, 34 (26) :4173-4176

[3]

BARTON DHR, 1975, J AM CHEM SOC P1, V15, P1574

[4] RECOGNITION OF DOUBLE HELICAL DNA BY ALTERNATE STRAND TRIPLE HELIX FORMATION [J].

BEAL, PA ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (13) :4976-4982

[5]

FESENFELD G, 1957, J AM CHEM SOC, V79, P2023

[6] TRIPLE-HELIX FORMATION AND COOPERATIVE BINDING BY OLIGODEOXYNUCLEOTIDES WITH A 3'-3' INTERNUCLEOTIDE JUNCTION [J].

FROEHLER, BC ;

TERHORST, T ;

SHAW, JP ;

MCCURDY, SN .

BIOCHEMISTRY, 1992, 31 (06) :1603-1609

[7] RECOGNITION OF MIXED-SEQUENCE DUPLEX DNA BY ALTERNATE-STRAND TRIPLE-HELIX FORMATION [J].

HORNE, DA ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (06) :2435-2437

[8] OLIGONUCLEOTIDE-DIRECTED TRIPLE HELIX FORMATION AT ADJACENT OLIGOPURINE AND OLIGOPYRIMIDINE DNA TRACTS BY ALTERNATE STRAND RECOGNITION [J].

JAYASENA, SD ;

JOHNSTON, BH .

NUCLEIC ACIDS RESEARCH, 1992, 20 (20) :5279-5288

[9] OLIGONUCLEOTIDES CONTAINING A COVALENT CONFORMATIONALLY RESTRICTED PHOSPHODIESTER ANALOG FOR HIGH-AFFINITY TRIPLE-HELIX FORMATION - THE RIBOACETAL INTERNUCLEOTIDE LINKAGE [J].

JONES, RJ ;

SWAMINATHAN, S ;

MILLIGAN, JF ;

WADWANI, S ;

FROEHLER, BC ;

MATTEUCCI, MD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) :9816-9817

[10] DEOXYOLIGONUCLEOTIDES WITH INVERTED POLARITY - SYNTHESIS AND USE IN TRIPLE-HELIX FORMATION [J].

MCCURDY, S ;

MOULDS, C ;

FROEHLER, B .

NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3) :287-290