SYNTHETIC, STRUCTURAL, AND CONFORMATIONAL STUDIES OF METHYLATED RING-EXPANDED NUCLEOSIDES CONTAINING THE IMIDAZO[4,5-E][1,4]DIAZEPINE RING-SYSTEM

被引：17

作者：

HOSMANE, RS ^{[1
]}

BHAN, A ^{[1
]}

HULCE, M ^{[1
]}

ZHANG, HM ^{[1
]}

HOSMANE, NS ^{[1
]}

机构：

[1] SO METHODIST UNIV,DEPT CHEM,DALLAS,TX 75275

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319108046664

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syntheses of 4- and 7-methyl 4,5,7,8-tetrahydro-6H-3-(beta-D-ribofuranosyl)imidazo[4, 5-e] [1,4]diazepine-5,8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.

引用

页码：819 / 836

页数：18

共 17 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2]

Derome A. E., 1987, MODERN NMR TECHNIQUE

[3]

HALL L D, 1980, Journal of the American Chemical Society, V102, P5703, DOI 10.1021/ja00538a001

[4] PYRIMIDINE NUCLEOSIDE CONFORMATIONAL ANALYSIS - NUCLEAR OVERHAUSER EFFECT AND CIRCULAR DICHROISM CORRELATIONS [J].