INDUCTION OF HEPATIC P450-DEPENDENT MONOOXYGENASE IN FERAL MICE FROM A PCDD PCDF-CONTAMINATED AREA

被引：12

作者：

SCHRENK, D

LIPP, HP

BRUNNER, H

WIESMULLER, T

HAGENMAIER, H

BOCK, KW

机构：

[1] UNIV TUBINGEN,INST TOXICOL,W-7400 TUBINGEN 1,GERMANY

[2] UNIV TUBINGEN,INST ORGAN CHEM,W-7400 TUBINGEN 1,GERMANY

来源：

CHEMOSPHERE | 1991年 / 22卷 / 11期

关键词：

D O I：

10.1016/0045-6535(91)90302-T

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Increased PCDD/PCDF levels were detectable in liver of feral mice (Microtus arvalis) living in PCDD/PCDF contaminated areas (up to 27800 ng TE/kg soil) of a former cable pyrolysis plant, in comparison with animals from a control area. The pattern of PCDD/PCDF congeners showed marked differences between soil and liver. Hepatic 7-ethoxyresorufin O-deethylase (EROD; a functional parameter for PCDD/PCDF-inducible cytochrome P450IA1) was increased in feral mice in relation to the degree of soil contamination with PCDD/PCDF. The data suggest that hepatic EROD activity is a useful bioindicator of the exposure of wild mammalian populations with PCDD/PCDF.

引用

收藏

页码：1011 / 1018

页数：8

相关论文

共 12 条

[1] CORRELATION OF POLYCHLORINATED DIBENZODIOXIN LEVELS WITH HEPATIC MIXED-FUNCTION OXIDASE INDUCTION IN GREAT BLUE HERONS [J].

BELLWARD, GD ;

NORSTROM, RJ ;

WHITEHEAD, PE ;

ELLIOTT, JE ;

BANDIERA, SM ;

DWORSCHAK, C ;

CHANG, T ;

FORBES, S ;

CADARIO, B .

CHEMOSPHERE, 1990, 20 (7-9) :1087-1090

[2]

BURKE MD, 1974, DRUG METAB DISPOS, V2, P583

[3] INTERACTIONS OF RUTAECARPINE ALKALOIDS WITH SPECIFIC BINDING-SITES FOR 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN IN RAT-LIVER [J].

GILLNER, M ;

BERGMAN, J ;

CAMBILLAU, C ;

GUSTAFSSON, JA .

CARCINOGENESIS, 1989, 10 (04) :651-654

[4]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[5] P450 GENES - STRUCTURE, EVOLUTION, AND REGULATION [J].

NEBERT, DW ;

GONZALEZ, FJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :945-993

[6] RESPONSES OF BIOTRANSFORMATION ENZYMES IN FISH LIVER - EXPERIMENTS WITH PULPMILL EFFLUENTS AND THEIR COMPONENTS [J].

OIKARI, A ;

LINDSTROMSEPPA, P .

CHEMOSPHERE, 1990, 20 (7-9) :1079-1085

[7] REVIEW AND PERSPECTIVE ON THE USE OF MIXED-FUNCTION OXYGENASE ENZYMES IN BIOLOGICAL MONITORING [J].

PAYNE, JF ;

FANCEY, LL ;

RAHIMTULA, AD ;

PORTER, EL .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1987, 86 (02) :233-245

[8] 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN AND RELATED HALOGENATED AROMATIC-HYDROCARBONS - EXAMINATION OF THE MECHANISM OF TOXICITY [J].

POLAND, A ;

KNUTSON, JC .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1982, 22 :517-554

[9] COMPARATIVE TOXICOLOGY AND MECHANISM OF ACTION OF POLYCHLORINATED DIBENZO-P-DIOXINS AND DIBENZOFURANS [J].

SAFE, SH .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1986, 26 :371-399

[10] ASSESSMENT OF BIOLOGICAL-ACTIVITIES OF MIXTURES OF POLYCHLORINATED DIBENZO-P-DIOXINS - COMPARISON BETWEEN DEFINED MIXTURES AND THEIR CONSTITUENTS [J].

SCHRENK, D ;

LIPP, HP ;

WIESMULLER, T ;

HAGENMAIER, H ;

BOCK, KW .

ARCHIVES OF TOXICOLOGY, 1991, 65 (02) :114-118