SUPPRESSION OF PROGRAMMED NEURONAL DEATH BY SUSTAINED ELEVATION OF CYTOPLASMIC CALCIUM

被引：342

作者：

FRANKLIN, JL

JOHNSON, EM

机构：

[1] Dept of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 12期

关键词：

D O I：

10.1016/0166-2236(92)90103-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic depolarization greatly increases the survival of many types of neurons in culture. In at least some cases this enhancement of survival consists of the suppression of Programmed cell death, a type of death occurring in developing neurons deprived of sufficient neurotrophic factor support. Available evidence suggests that the effect of depolarization on survival is mediated by a sustained rise of cytoplasmic free Ca2+, apparently caused by influx of Ca2+ through voltage-gated channels. This review discusses what is known about the mechanism by which prolonged depolarization and increased intracellular Ca2+ promote survival.

引用

页码：501 / 508

页数：8

共 61 条

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