LOSS OF HETEROZYGOSITY ON CHROMOSOME-22 IN OVARIAN-CARCINOMA IS DISTAL TO AND IS NOT ACCOMPANIED BY MUTATIONS IN NF2 AT 22Q12

被引：40

作者：

ENGLEFIELD, P

FOULKES, WD

CAMPBELL, IG

机构：

[1] UNIV SOUTHAMPTON,PRINCESS ANNE HOSP,SOUTHAMPTON SO15 5YA,HANTS,ENGLAND

[2] IMPERIAL CANC RES FUND,HUMAN IMMUNOGENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 70卷 / 05期

关键词：

D O I：

10.1038/bjc.1994.418

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Frequent loss of heterozygosity (LOH) has been reported on 22q in ovarian carcinoma, implying the presence of a tumour-suppressor gene. The neurofibromatosis type 2 gene (NF2) at 22q12 is a plausible candidate. Analysis of 9 of the 17 exons of NF2 by single-strand conformational polymorphism (SSCP) in 67 ovarian carcinomas did not detect any somatic mutations, suggesting that NF2 is not involved in the pathogenesis of ovarian carcinoma. LOH data support this conclusion and that the putative tumour-suppressor gene lies distal to NF2, beyond D22S283.

引用

页码：905 / 907

页数：3

共 32 条

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