ELECTRORETINOGRAPHIC EFFECTS OF HALOPERIDOL ON THE MOUSE RETINA

被引：9

作者：

MIZOTA, A

ADACHIUSAMI, E

机构：

[1] Department of Ophthalmology, Chiba University School of Medicine, Chiba, 260, 1-8-1 Inohana, Chuo-ku

来源：

DOCUMENTA OPHTHALMOLOGICA | 1993年 / 85卷 / 02期

关键词：

AMPLITUDE VERSUS STIMULUS INTENSITY CURVE; DOPAMINE ANTAGONIST; DOSE-RELATED STUDY; ELECTRORETINOGRAM; HALOPERIDOL;

D O I：

10.1007/BF01371130

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The effects of haloperidol on the electroretinogram were studied in mice injected intraperitoneally with haloperidol. A dose-related study was performed. A significant decrease in the amplitude of the b-wave was found in the mice injected with more than 20 mg/kg of haloperidol. However, the peak latency of the b-wave and the stimulus intensity required to elicit a b-wave of one half of the maximum b-wave amplitude remained unchanged. No significant changes were found in the a-wave. This change in the electroretinogram recovered 24 hours after the injection. These results suggest that functional change occurred at the retinal level after intraperitoneal injection

引用

页码：151 / 160

页数：10

共 18 条

[1] HALOPERIDOL DELAYS VISUALLY EVOKED CORTICAL POTENTIALS BUT NOT ELECTRORETINOGRAMS IN MICE [J].