MONOCLONAL-ANTIBODY KS1/4-METHOTREXATE IMMUNOCONJUGATE STUDIES IN NONSMALL CELL LUNG-CARCINOMA
被引:29
作者:
ELIAS, DJ
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SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT PATHOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USASCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
ELIAS, DJ
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KLINE, LE
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
KLINE, LE
ROBBINS, BA
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
ROBBINS, BA
JOHNSON, HCL
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
JOHNSON, HCL
PEKNY, K
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
PEKNY, K
BENZ, M
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
BENZ, M
ROBB, JA
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
ROBB, JA
WALKER, LE
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
WALKER, LE
KOSTY, M
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
KOSTY, M
DILLMAN, RO
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机构:SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
DILLMAN, RO
机构:
[1] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
[2] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT PATHOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
[3] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
The antigen reactive with murine monoclonal antibody (MAb) KS1/4 is expressed on epithelial malignancies and some normal epithelial tissues. Studies were undertaken to evaluate KS1/4-methotrexate (KS1/4-MTX) immunoconjugate in patients with advanced non-small cell carcinoma of the lung. Eleven patients in two different groups received KS1/4-MTX in two different escalating dose infusion schedules with a maximal tolerated dose of 1,750 mg/M(2) and a cumulative dose of MTX of 40 mg/M(2). Toxicities were similar in both groups and included fever, anorexia, nausea, vomiting, diarrhea, abdominal pain, guaiac positive stool, and hypoalbuminemia. Two patients had an associated aseptic meningitis. One patient had a 50% decrease in two lung nodules without a change in lymphangitic infiltrates. This patient received a second course of treatment and developed an immune complex-mediated arthritis and serum sickness. Four patients mounted a human antimouse antibody response. Post-treatment tumor biopsies documented binding of MAb KS1/4. These studies document the feasibility and potential usefulness of a MAb directed against tumor-associated antigens with the targeting of chemotherapeutic drugs in patients with non-small cell lung carcinoma.