MONOCLONAL-ANTIBODY KS1/4-METHOTREXATE IMMUNOCONJUGATE STUDIES IN NONSMALL CELL LUNG-CARCINOMA

被引:29
作者
ELIAS, DJ [2 ]
KLINE, LE
ROBBINS, BA
JOHNSON, HCL
PEKNY, K
BENZ, M
ROBB, JA
WALKER, LE
KOSTY, M
DILLMAN, RO
机构
[1] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
[2] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT PATHOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
[3] SCRIPPS RES INST, IDA M & CECIL H GREEN CANC CTR, DEPT IMMUNOL, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA
关键词
D O I
10.1164/ajrccm.150.4.7921445
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The antigen reactive with murine monoclonal antibody (MAb) KS1/4 is expressed on epithelial malignancies and some normal epithelial tissues. Studies were undertaken to evaluate KS1/4-methotrexate (KS1/4-MTX) immunoconjugate in patients with advanced non-small cell carcinoma of the lung. Eleven patients in two different groups received KS1/4-MTX in two different escalating dose infusion schedules with a maximal tolerated dose of 1,750 mg/M(2) and a cumulative dose of MTX of 40 mg/M(2). Toxicities were similar in both groups and included fever, anorexia, nausea, vomiting, diarrhea, abdominal pain, guaiac positive stool, and hypoalbuminemia. Two patients had an associated aseptic meningitis. One patient had a 50% decrease in two lung nodules without a change in lymphangitic infiltrates. This patient received a second course of treatment and developed an immune complex-mediated arthritis and serum sickness. Four patients mounted a human antimouse antibody response. Post-treatment tumor biopsies documented binding of MAb KS1/4. These studies document the feasibility and potential usefulness of a MAb directed against tumor-associated antigens with the targeting of chemotherapeutic drugs in patients with non-small cell lung carcinoma.
引用
收藏
页码:1114 / 1122
页数:9
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