PHENACYL-DIRECTED ALKYLATION OF IMIDAZOLES - A NEW REGIOSPECIFIC SYNTHESIS OF 3-SUBSTITUTED L-HISTIDINES

被引：34

作者：

CHIVIKAS, CJ ^{[1
]}

HODGES, JC ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS PHARMACEUT RES,ANN ARBOR,MI 48105

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1987年 / 52卷 / 16期

关键词：

D O I：

10.1021/jo00392a018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：3591 / 3594

页数：4

共 9 条

[1] POTENTIAL HISTAMINE H2-RECEPTOR ANTAGONISTS .3. METHYLHISTAMINES [J].

DURANT, GJ ;

EMMETT, JC ;

GANELLIN, CR ;

ROE, AM ;

SLATER, RA .

JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (07) :923-928

[2] SYNTHESIS OF N-PI-ALKYLHISTAMINES [J].

EMMETT, JC ;

HOLLOWAY, FH ;

TURNER, JL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (05) :1341-1344

[3] USE OF THE N(PI)-PHENACYL GROUP FOR THE PROTECTION OF THE HISTIDINE SIDE-CHAIN IN PEPTIDE-SYNTHESIS [J].

FLETCHER, AR ;

JONES, JH ;

RAMAGE, WI ;

STACHULSKI, AV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (09) :2261-2267

[4]

FLETCHER AR, 1984, J CHEM SOC CHEM COMM, P292

[5] EFFICIENT AND SELECTIVE METHOD FOR SYNTHESIS OF 2-(4-FLUOROPHENYL)-1-(2-HYDROXYETHYL)-5-NITROIMIDAZOLE (FLUNIDAZOLE) [J].

GRABOWSK.EJ ;

LIU, TMH ;

SALCE, L ;

SCHOENEW.EF .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (05) :547-549

[6]

HODGES JC, 1987, SYNTHESIS-STUTTGART, P20

[7]

JONES JH, 1982, Patent No. 61933

[8]

NOORDAM A, 1978, RECL TRAV CHIM PAY B, V97, P293

[9]

SCHLOGL K, 1956, MONATSH CHEM, V87, P680

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