DEVELOPMENT OF A NEW PHYSICOCHEMICAL MODEL FOR BRAIN PENETRATION AND ITS APPLICATION TO THE DESIGN OF CENTRALLY ACTING H-2-RECEPTOR HISTAMINE-ANTAGONISTS

被引：477

作者：

YOUNG, RC

MITCHELL, RC

BROWN, TH

GANELLIN, CR

GRIFFITHS, R

JONES, M

RANA, KK

SAUNDERS, D

SMITH, IR

SORE, NE

WILKS, TJ

机构：

来源：

关键词：

D O I：

10.1021/jm00398a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：656 / 671

页数：16

共 72 条

[1] ALBERT A, 1984, DETERMINATION IONIZA, P154
[2] STUDIES IN CHEMOTHERAPY .10. ANTITHYROID COMPOUNDS - SYNTHESIS OF 5-SUBSTITUTED AND 6-SUBSTITUTED 2-THIOURACILS FROM BETA-OXOESTERS AND THIOUREA
ANDERSON, GW
HALVERSTADT, IF
MILLER, WH
ROBLIN, RO
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1945, 67 (12) : 2197 - 2200
[3] ARMITAGE MA, 1986, J LABELLED COMPD RAD, V24, P431
[4] UBER THIAZOLE .40. SYNTHESEN VON THIAZOLYL-(2)-GUANIDINEN
BEYER, H
HANTSCHEL, H
[J]. CHEMISCHE BERICHTE-RECUEIL, 1962, 95 (04): : 893 - &
[5] BLAKEMORE RC, 1983, BR J PHARM P S, V80, pP437
[6] BLAKEMORE RC, 1981, P BR PHARM, V74, pP200
[7] BRADSHAW J, 1979, BRIT J PHARMACOL, V66, pP464
[8] BRADSHAW J, 1980, Patent No. 1565966
[9] CIMETIDINE - NON-THIOUREA H2-RECEPTOR ANTAGONIST
BRIMBLECOMBE, RW
DUNCAN, WAM
DURANT, GJ
EMMETT, JC
GANELLIN, CR
PARSONS, ME
[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1975, 3 (02) : 86 - 92
[10] BRITTAIN R T, 1982, British Journal of Pharmacology, V76, p195P