EFFECTS OF THE REACTION CONDITIONS ON THE ENANTIO-SELECTIVE ESTERIFICATION USING CANDIDA-CYLINDRACEA LIPASE

被引：16

作者：

GUBICZA, L

SZAKACSSCHMIDT, A

机构：

[1] Research Institute for Chemical Engineering of the Hungarian Academy of Sciences, H-8200 Veszprém

来源：

BIOCATALYSIS | 1994年 / 9卷 / 1-4期

基金：

匈牙利科学研究基金会;

关键词：

CANDIDA-CYLINDRACEA LIPASE; ENZYMATIC ESTERIFICATION; SYNTHETIC ACTIVITY; ENANTIOSELECTIVITY; ORGANIC MEDIA;

D O I：

10.3109/10242429408992115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parameters influencing the synthetic activity and enantioselectivity of the Candida cylindracea lipase were investigated. The test reaction was presented through the enantioselective esterification of 2-substituted propionic acids in organic solvents. It was found that both the activity and the enantioselectivity of the lipase could be most effectively influenced by solvent engineering. Since the solvent has a different effect on activity and enantioselectivity of the lipase, selection of the most suitable solvent or solvent mixture is an important optimization question.

引用

页码：131 / 143

页数：13

共 20 条

[1] ENANTIOMERIC SEPARATION OF 2-CHLOROPROPIONIC ACID BY ENZYMATIC ESTERIFICATION IN ORGANIC-SOLVENTS [J].