MOLECULAR CHARACTERIZATION OF THE GENE ENCODING HIGH-LEVEL MUPIROCIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS J2870

被引:109
作者
HODGSON, JE
CURNOCK, SP
DYKE, KGH
MORRIS, R
SYLVESTER, DR
GROSS, MS
机构
[1] UNIV OXFORD,DEPT BIOCHEM,MICROBIOL UNIT,OXFORD OX1 3QU,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,BIOPHARMACEUT R&D,KING OF PRUSSIA,PA 19406
关键词
D O I
10.1128/AAC.38.5.1205
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.
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页码:1205 / 1208
页数:4
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