EVIDENCE FROM CASSETTE MUTAGENESIS FOR A STRUCTURE-FUNCTION MOTIF IN A PROTEIN OF UNKNOWN STRUCTURE

被引:35
作者
CLARKE, ND [1 ]
LIEN, DC [1 ]
SCHIMMEL, P [1 ]
机构
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
关键词
D O I
10.1126/science.3282306
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:521 / 523
页数:3
相关论文
共 20 条
[1]   TYROSYL-TRANSFER RNA-SYNTHETASE FORMS A MONONUCLEOTIDE-BINDING FOLD [J].
BHAT, TN ;
BLOW, DM ;
BRICK, P ;
NYBORG, J .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (04) :699-709
[2]   BUFFER GRADIENT GELS AND S-35 LABEL AS AN AID TO RAPID DNA-SEQUENCE DETERMINATION [J].
BIGGIN, MD ;
GIBSON, TJ ;
HONG, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :3963-3965
[3]   STRUCTURAL HOMOLOGY IN THE AMINO-TERMINAL DOMAINS OF 2 AMINOACYL-TRANSFER RNA-SYNTHETASES [J].
BLOW, DM ;
BHAT, TN ;
METCALFE, A ;
RISLER, JL ;
BRUNIE, S ;
ZELWER, C .
JOURNAL OF MOLECULAR BIOLOGY, 1983, 171 (04) :571-576
[4]  
BLOW DM, 1985, BIOL MACROMOL, V2, P442
[5]   THE VALYL-TRANSFER RNA-SYNTHETASE FROM BACILLUS-STEAROTHERMOPHILUS HAS CONSIDERABLE SEQUENCE HOMOLOGY WITH THE ISOLEUCYL-TRANSFER RNA-SYNTHETASE FROM ESCHERICHIA-COLI [J].
BORGFORD, TJ ;
BRAND, NJ ;
GRAY, TE ;
FERSHT, AR .
BIOCHEMISTRY, 1987, 26 (09) :2480-2486
[6]  
CLARKE ND, 1987, THESIS MIT CAMBRIDGE
[7]   ISOLEUCYL TRANSFER RIBONUCLEIC ACID SYNTHETASE - ROLE OF MAGNESIUM IN AMINO ACID ACTIVATION [J].
COLE, FX ;
SCHIMMEL, PR .
BIOCHEMISTRY, 1970, 9 (16) :3143-&
[8]   STRUCTURE OF THE YEAST ISOLEUCYL-TRANSFER RNA-SYNTHETASE GENE (ILS1) - DNA-SEQUENCE, AMINO-ACID-SEQUENCE OF PROTEOLYTIC PEPTIDES OF THE ENZYME AND COMPARISON OF THE STRUCTURE TO THOSE OF OTHER KNOWN AMINOACYL-TRANSFER RNA-SYNTHETASES [J].
ENGLISCH, U ;
ENGLISCH, S ;
MARKMEYER, P ;
SCHISCHKOFF, J ;
STERNBACH, H ;
KRATZIN, H ;
CRAMER, F .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1987, 368 (08) :971-979
[9]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
[10]  
FERSHT AR, 1984, ANGEW CHEM, V94, P455