SERUM IRON, FERRITIN, AND VITAMIN-B12 DURING PROLONGED OMEPRAZOLE THERAPY

被引：83

作者：

KOOP, H ^{[1
]}

BACHEM, MG ^{[1
]}

机构：

[1] UNIV MARBURG,INST CLIN CHEM,W-3550 MARBURG,GERMANY

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1992年 / 14卷 / 04期

关键词：

FERRITIN; FOLIC ACID; IRON; OMEPRAZOLE; PEPTIC DISEASES; ACID SECRETION; VITAMIN-B12;

D O I：

10.1097/00004836-199206000-00005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Since gastric acid plays an important role in the absorption process of iron and vitamin B12, we determined levels of iron, ferritin, vitamin B12, and folic acid in 75 serum samples obtained during continuous omeprazole therapy (6-48 months after start of therapy) from 34 patients with peptic diseases (primarily reflux esophagitis). Serum iron and ferritin levels were decreased in two and three patients, respectively, but there is little evidence that omeprazole administration was causally related to these findings. Serum vitamin B12 and folic acid levels were normal in all cases. We conclude that iron, vitamin B12, and folic acid malabsorption is unlikely to occur, at least within the initial 3-4 years of continuous omeprazole therapy.

引用

页码：288 / 292

页数：5

共 24 条

[1] EFFECT OF PROTEOLYTIC-ENZYMES ON BINDING OF COBALAMIN TO R-PROTEIN AND INTRINSIC-FACTOR - INVITRO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R-PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY [J].