A CONVENIENT SYNTHESIS OF OLIGONUCLEOTIDES WITH A 3'-PHOSPHOGLYCOLATE AND 3'-PHOSPHOGLYCALDEHYDE TERMINUS

被引：33

作者：

URATA, H ^{[1
]}

AKAGI, M ^{[1
]}

机构：

[1] OSAKA UNIV PHARMACEUT SCI,2-10-65 KAWAI,MATSUBARA,OSAKA 580,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 25期

关键词：

OLIGONUCLEOTIDE; 3'-PHOSPHOGLYCOLATE; 3'-PHOSPHOGLYCALDEHYDE; BLEOMYCIN;

D O I：

10.1016/S0040-4039(00)60604-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and rapid method for solid phase synthesis of oligonucleotides carrying a 3'-phosphoglycerol terminus was developed. The modified oligonucleotide was readily oxidized by NaIO4 to a 3'-phosphoglycaldehyde. The treatment of this aldehyde with NaClO2 afforded a 3'-phosphoglycolate.

引用

页码：4015 / 4018

页数：4

共 17 条

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