GALECTIN-3 IS EXPRESSED IN THE NOTOCHORD, DEVELOPING BONES, AND SKIN OF THE POSTIMPLANTATION MOUSE EMBRYO

被引：76

作者：

FOWLIS, D ^{[1
]}

COLNOT, C ^{[1
]}

RIPOCHE, MA ^{[1
]}

POIRIER, F ^{[1
]}

机构：

[1] INST COCHIN GENET MOLEC,INSERM,U257,F-75014 PARIS,FRANCE

来源：

DEVELOPMENTAL DYNAMICS | 1995年 / 203卷 / 02期

关键词：

GALECTIN-3; MAC-2; MOUSE EMBRYOGENESIS; NOTOCHORD; CARTILAGE; EPIDERMIS;

D O I：

10.1002/aja.1002030211

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The galectins are a family of low molecular weight, calcium-independent mammalian carbohydrate binding proteins that exhibit specificity for beta-galactoside derivatives. We have examined the expression pattern of galectin-3 in the developing mouse embryo by in situ hybridisation and immunohistochemistry. In the embryo proper, galectin-3 message and protein are first detected in notochord, starting from 8.5 days post coitum (dpc), and persist until this structure disappears. Galectin-3 is later found in cartilage primordia and in developing skin from 13.5 dpc. This very restricted and dynamic pattern suggests that galectin-3 may participate in the establishment and/or maintenance of notochord as well as the formation of cartilage and differentiation of skin. Finally, we find that galectin-3, which is identical to the macrophage marker Mac-2, is also expressed in embryonic macrophages. (C) 1995 Wiley-Liss, Inc.

引用

页码：241 / 251

页数：11

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