STRUCTURE-ACTIVITY-RELATIONSHIPS OF SYNTHETIC DIGITOXIGENYL GLYCOSIDES

被引：12

作者：

TAKECHI, M

TANAKA, Y

机构：

[1] Faculty of Pharmaceutical Sciences Kinki University, Higashiosaka

来源：

PHYTOCHEMISTRY | 1994年 / 37卷 / 05期

关键词：

ANTIVIRAL ACTIVITY; CYTOTOXICITY; ANTI-ATPASE ACTIVITY; CORRELATION; DIGITOXIGENIN; GLYCOSIDE;

D O I：

10.1016/S0031-9422(00)90424-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Antiviral, cytotoxic and anti-ATPase activities of 14 synthetic digitoxigenyl glycosides were compared with each other. The activities of those containing gentiobioside and melibioside were much weaker than the others. On the other hand, the three activities were highly correlated with each other.

引用

收藏

页码：1421 / 1423

页数：3

相关论文

共 15 条

[1]

EFFECT OF SAPONINS FROM ANAGALLIS-ARVENSIS ON EXPERIMENTAL HERPES-SIMPLEX KERATITIS IN RABBITS [J].

AMOROS, M ;

FAUCONNIER, B ;

GIRRE, RL .

PLANTA MEDICA, 1988, (02) :128-131

[2]

ANTIVIRAL ACTIVITY OF GLYCYRRHIZIN AGAINST VARICELLA-ZOSTER VIRUS INVITRO [J].

BABA, M ;

SHIGETA, S .

ANTIVIRAL RESEARCH, 1987, 7 (02) :99-107

[3]

BALOGH V, 1971, J ORG CHEM, V36, P1399

[4]

BROWN L, 1981, ARZNEIMITTELFORSCH, V31-2, P1059

[5]

CARDENOLIDE ANALOGS .12. C-13 NMR OF SEMI-SYNTHETIC GLYCOSIDES AND SIDE-CHAIN MODIFIED GENINS [J].

CHEUNG, HTA ;

BROWN, L ;

BOUTAGY, J ;

THOMAS, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (06) :1773-1778

[6]

STRUCTURE AND INVITRO ANTIVIRAL ACTIVITY OF TRITERPENOID SAPONINS FROM CALENDULA-ARVENSIS [J].

DETOMMASI, N ;

CONTI, C ;

STEIN, ML ;

PIZZA, C .

PLANTA MEDICA, 1991, 57 (03) :250-253

[7]

INHIBITORY EFFECT OF GLYCYRRHIZIN ON THE INVITRO INFECTIVITY AND CYTOPATHIC ACTIVITY OF THE HUMAN-IMMUNODEFICIENCY-VIRUS [HIV(HTLV-III/LAV)] [J].

ITO, M ;

NAKASHIMA, H ;

BABA, M ;

PAUWELS, R ;

DECLERCQ, E ;

SHIGETA, S ;

YAMAMOTO, N .

ANTIVIRAL RESEARCH, 1987, 7 (03) :127-137

[8]

KAMANO Y, 1988, CHEM PHARM BULL, V36, P326

[9]

HIGHLY SPECIFIC SODIUM-POTASSIUM-ACTIVATED ADENOSINE TRIPHOSPHATASE FROM VARIOUS TISSUES OF RABBIT [J].

NAKAO, T ;

TASHIMA, Y ;

NAGANO, K ;

NAKAO, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 19 (06) :755-&

[10]

PETERS U, 1978, ARZNEIMITTEL-FORSCH, V28-1, P750