DEOXYSPERGUALIN DIRECTLY SUPPRESSES ANTIBODY-FORMATION INVIVO AND INVITRO

被引:67
作者
FUJII, H [1 ]
TAKADA, T [1 ]
NEMOTO, K [1 ]
YAMASHITA, T [1 ]
ABE, F [1 ]
FUJII, A [1 ]
TAKEUCHI, T [1 ]
机构
[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN
关键词
D O I
10.7164/antibiotics.43.213
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The effect of deoxyspergualin (DSG, NKT-01) on humoral immunity was investigated both in vitro and in vivo. DSG inhibited the primary and secondary responses to T cell-dependent antigens and the response to T cell-independent antigens in thymic and athymic mice. However, natural antibodies in non-sensitized mice were affected less by the administration of DSG. The agent produced a dose-dependent inhibition of B cell proliferation and antibody production to lipopolysaccharide in vitro. Suppression of secondary antibody response was also shown, whenever antigen stimulation was not given, antibody production was not affected. These results suggest that DSG affects the proliferative stage of B lymphocytes in such a way as to inhibit their growth and antibody production. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:213 / 219
页数:7
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