IDENTIFICATION OF 2 NOVEL COCAINE METABOLITES IN BILE BY GAS-CHROMATOGRAPHY AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY IN A CASE OF ACUTE INTRAVENOUS COCAINE OVERDOSE

被引：27

作者：

LOWRY, WT ^{[1
]}

LOMONTE, JN ^{[1
]}

HATCHETT, D ^{[1
]}

GARRIOTT, JC ^{[1
]}

机构：

[1] SW INST FORENS SCI,TOXICOL LAB,DALLAS,TX 75235

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1979年 / 3卷 / 03期

关键词：

D O I：

10.1093/jat/3.3.91

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cocaine and five of Its metabolitoc were detected in an alkaline extraction of human bile by gas chromatography and were Identified by gas chromatography/mass spectrometry. Among the motabolltes Identified were benzoylocgonine, hydroxycocaine, methylocgonidlne, methylocgonlne, and norcocalne. Very little information has appeared until now regarding methylecgonldlne, methylocgonlne, and hydroxycocaine. © 1979 Oxford University Press.

引用

页码：91 / 95

页数：5

共 5 条

[1] RAPID, COMPREHENSIVE SCREENING-PROCEDURE FOR BASIC DRUGS IN BLOOD OR TISSUES BY GAS-CHROMATOGRAPHY
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GARRIOTT, JC
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 1978, 2 (02) : 50 - 55
[2] NORCOCAINE - PHARMACOLOGICALLY ACTIVE METABOLITE OF COCAINE FOUND IN BRAIN
HAWKS, RL
KOPIN, IJ
COLBURN, RW
THOA, NB
[J]. LIFE SCIENCES, 1974, 15 (12) : 2189 - 2195
[3] HAWKS RL, 1977, COCAINE 1977, P50
[4] ESTIMATION AND DISPOSITION OF [BENZOYLECGONINE-H-3] AND PHARMACOLOGICAL ACTIVITY OF SOME COCAINE METABOLITES
MISRA, AL
NAYAK, PK
BLOCH, R
MULE, SJ
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (10) : 784 - 786
[5] WOODS LA, 1951, J PHARMACOL EXP THER, V101, P200

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