THROMBOXANE RECEPTOR ANTAGONISM COMBINED WITH THROMBOXANE SYNTHASE INHIBITION .6. 4-SUBSTITUTED 3-PYRIDINYLALKANOIC ACIDS

被引：7

作者：

BHAGWAT, SS

BOSWELL, C

GUDE, C

CONTARDO, N

COHEN, DS

MATHIS, J

DOTSON, R

LEE, W

SHETTY, S

机构：

[1] Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, NJ 07901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80442-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(3-Pyridinyl)alkanoic acids substituted at the 4-position with an (arylsulfonamido)alkyl group were synthesized and found to behave as platelet thromboxane receptor antagonists (TxRAs) and thromboxane synthase inhibitors (TxSls). The compounds behaved as agonists at the vascular receptor for thromboxane A2.

引用

页码：1619 / 1622

页数：4

共 18 条

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