2 DISTINCT TYPES OF AMPA RESPONSES IN CULTURED RAT HIPPOCAMPAL-NEURONS

被引：43

作者：

OZAWA, S

IINO, M

机构：

[1] Department of Physiology, School of Medicine, Gunma University. Maebashi., Gunma

来源：

NEUROSCIENCE LETTERS | 1993年 / 155卷 / 02期

关键词：

GLUTAMATE RECEPTOR; AMPA; KAINATE; GLUR2; SUBUNIT; CA-2+ PERMEABILITY; CURRENT-VOLTAGE RELATION; HIPPOCAMPAL NEURON;

D O I：

10.1016/0304-3940(93)90704-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously found two distinct types of responses to kainate in cultured rat hippocampal neurons. The type I response is characterized by very little increase in Ca2+ permeability with an outward rectification in the current voltage (I-V) relation of the kainate response. In contrast, the type II kainate response is characterized by prominent Ca2+ permeability and an inward rectification. These two types of responses were mimicked by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA). Furthermore, AMPA cross-desensitized both types of kainate responses. These results indicate that two functionally different types of AMPA/kainate receptors are expressed in hippocampal neurons.

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页码：187 / 190

页数：4

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