THE ANTICONVULSANT EFFECT OF THE BROAD-SPECTRUM ANTICONVULSANT LORECLEZOLE MAY BE MEDIATED IN PART BY SEROTONIN IN RATS - A MICRODIALYSIS STUDY

被引：15

作者：

DAILEY, JW ^{[1
]}

SEO, DO ^{[1
]}

YAN, QS ^{[1
]}

KO, KH ^{[1
]}

JO, MJ ^{[1
]}

JOBE, PC ^{[1
]}

机构：

[1] SEOUL NATL UNIV,COLL PHARM,CTR BIOFUNCT MOLEC,POSTECH,SEOUL 151,SOUTH KOREA

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

LORECLEZOLE; SEROTONIN; GENETICALLY EPILEPSY-PRONE RAT; MICRODIALYSIS; ANTICONVULSANT EFFECT; 5-HYDROXYTRYPTOPHAN;

D O I：

10.1016/0304-3940(94)90754-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Loreclezole is an experimental anticonvulsant drug. We found previously that several established anticonvulsants increase extracellular serotonin as measured by microdialysis. We have concluded that the increase in extracellular serotonin and the anticonvulsant effect produced by these anticonvulsant drugs are related in a cause and effect manner. To determine if anticonvulsant doses of loreclezole increase extracellular serotonin, we determined anticonvulsant dose-response relationships in genetically epilepsy-prone rats (GEPRs). Then, we administered ED(99) doses of loreclezole to GEPRs and determined the effect on extracellular serotonin as measured by microdialysis in the striatum. We conclude that loreclezole produces a dose-related anticonvulsant effect in GEPRs and that anticonvulsant doses of loreclezole increase extracellular serotonin in these animals.

引用

页码：179 / 183

页数：5

共 33 条

[1] ASTHTON D, 1992, EPILEPSY RES, V11, P75
[2] EFFECTS OF LORECLEZOLE ON EPILEPTIC ACTIVITY AND ON EEG AND BEHAVIOR IN RATS WITH ABSENCE SEIZURES
ATES, N
VANLUIJTELAAR, ELJM
DRINKENBURG, WHIM
VOSSEN, JMH
COENEN, AML
[J]. EPILEPSY RESEARCH, 1992, 13 (01) : 43 - 48
[3] REGIONAL EFFECTS OF SODIUM VALPROATE ON EXTRACELLULAR CONCENTRATIONS OF 5-HYDROXYTRYPTAMINE, DOPAMINE, AND THEIR METABOLITES IN THE RAT-BRAIN - AN INVIVO MICRODIALYSIS STUDY
BIGGS, CS
PEARCE, BR
FOWLER, LJ
WHITTON, PS
[J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) : 1702 - 1708
[4] BOOKER JG, 1986, LIFE SCI, V39, P799
[5] ELECTROSHOCK-INDUCED AND PENTYLENETETRAZOL-INDUCED SEIZURES IN GENETICALLY EPILEPSY-PRONE RATS (GEPRS) - DIFFERENCES IN THRESHOLD AND PATTERN
BROWNING, RA
WANG, C
LANKER, ML
JOBE, PC
[J]. EPILEPSY RESEARCH, 1990, 6 (01) : 1 - 11
[6] BROWNING RA, 1989, J PHARMACOL EXP THER, V249, P22
[7] SEROTONERGIC ABNORMALITIES IN THE CENTRAL-NERVOUS-SYSTEM OF SEIZURE-NAIVE GENETICALLY EPILEPSY-PRONE RATS
DAILEY, JW
MISHRA, PK
KO, KH
PENNY, JE
JOBE, PC
[J]. LIFE SCIENCES, 1992, 50 (04) : 319 - 326
[8] NORADRENERGIC ABNORMALITIES IN THE CENTRAL-NERVOUS-SYSTEM OF SEIZURE-NAIVE GENETICALLY EPILEPSY-PRONE RATS
DAILEY, JW
MISHRA, PK
KO, KH
PENNY, JE
JOBE, PC
[J]. EPILEPSIA, 1991, 32 (02) : 168 - 173
[9] NEUROBIOLOGY OF SEIZURE PREDISPOSITION IN THE GENETICALLY EPILEPSY-PRONE RAT
DAILEY, JW
REIGEL, CE
MISHRA, PK
JOBE, PC
[J]. EPILEPSY RESEARCH, 1989, 3 (01) : 3 - 17
[10] DAILEY JW, 1992, J PHARMACOL EXP THER, V260, P533

← 1 2 3 4 →