THE ANTICONVULSANT EFFECT OF THE BROAD-SPECTRUM ANTICONVULSANT LORECLEZOLE MAY BE MEDIATED IN PART BY SEROTONIN IN RATS - A MICRODIALYSIS STUDY

被引：15

作者：

DAILEY, JW ^{[1
]}

SEO, DO ^{[1
]}

YAN, QS ^{[1
]}

KO, KH ^{[1
]}

JO, MJ ^{[1
]}

JOBE, PC ^{[1
]}

机构：

[1] SEOUL NATL UNIV,COLL PHARM,CTR BIOFUNCT MOLEC,POSTECH,SEOUL 151,SOUTH KOREA

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

LORECLEZOLE; SEROTONIN; GENETICALLY EPILEPSY-PRONE RAT; MICRODIALYSIS; ANTICONVULSANT EFFECT; 5-HYDROXYTRYPTOPHAN;

D O I：

10.1016/0304-3940(94)90754-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Loreclezole is an experimental anticonvulsant drug. We found previously that several established anticonvulsants increase extracellular serotonin as measured by microdialysis. We have concluded that the increase in extracellular serotonin and the anticonvulsant effect produced by these anticonvulsant drugs are related in a cause and effect manner. To determine if anticonvulsant doses of loreclezole increase extracellular serotonin, we determined anticonvulsant dose-response relationships in genetically epilepsy-prone rats (GEPRs). Then, we administered ED(99) doses of loreclezole to GEPRs and determined the effect on extracellular serotonin as measured by microdialysis in the striatum. We conclude that loreclezole produces a dose-related anticonvulsant effect in GEPRs and that anticonvulsant doses of loreclezole increase extracellular serotonin in these animals.

引用

页码：179 / 183

页数：5

共 33 条

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