PROPERTIES OF MELANOSOMES AND THEIR EXPLOITATION IN THE DIAGNOSIS AND TREATMENT OF MELANOMA

被引：7

作者：

BOROVANSKY, J

机构：

[1] Department of Medical Biochemistry, Charles University, 12853

来源：

MELANOMA RESEARCH | 1993年 / 3卷 / 03期

关键词：

MELANIN; MELANOMA; MELANOSOME; PIGMENT CELL;

D O I：

10.1097/00008390-199306000-00006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanosomes are subcellular organelles with unique properties: they are producers and scavengers of cytotoxic quinones and are involved in free radical reactions. They behave as energy absorbing and converting devices, have an ion-exchange capacity and show affinity to a variety of substances. Even in the absence of melanin, premelanosomes show characteristic properties due to the presence of specific proteins. The melanosome concentration in pigment tissues is high enough to offer possibilities for influencing pigment cells and for detecting and/or killing melanoma cells. The exploitation of melanosome properties in practice is reviewed.

引用

页码：181 / 186

页数：6

共 76 条

[21]

Borovansky J., Mirejovsky P., Riley P.A., Possible relationship between abnormal melanosome structure and cytotoxic phenomena in malignant melanoma, Neoplasma, 38, pp. 393-400, (1991)

[22]

Riley P.A., Hydroxyanisole: Recent Advances in Anti-Melanoma Therapy, pp. 1-248, (1984)

[23]

Rilev P.A., Radicals and melanomas, Phil Trans R Soc Lend, B311, pp. 679-689, (1985)

[24]

Mason H.S., Ingram H.E., Allen B., Free radical properties of melanins, Arch Bwchem Biophys, 86, pp. 225-230, (1960)

[25]

Hill H.Z., The function of melanin or six blind people examine an elephant, Bioessays, 14, pp. 49-56, (1992)

[26]

Magomedov N.M., Dzhafarov A.I., Yusifov EY. On melanin role in regulation of free radical processes in the eye pigmental epithelium under the acute hypoxia, (In Russian) Biojysika, 35, pp. 977-980, (1990)

[27]

Koga S., Nakano M., Ito T., Importance of iron in lipid peroxidation in the tyrosinase 4-hydroxyanisole system: Possible mechanisms of killing of malignant melanoma cells by 4-hvdroxvanisole, Biochem Int, 26, pp. 397-403, (1992)

[28]

Hill H.Z., Hill G.J., Eumelanin causes DNA strand breaks and kills cells, Pigment Cell Res, 1, pp. 163-170, (1987)

[29]

Offner M.A., Wirtz H.C., Schiefer J., Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals, Am J Pathol, 141, pp. 601-610, (1992)

[30]

Mc Ginness J., Proctor P., The importance of the fact that melanin is black, J Theor Biol, 39, pp. 677-678, (1973)

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