THE ASSOCIATION OF INFLAMMATORY BOWEL-DISEASE AND LEUKEMIA - COINCIDENCE OR NOT

被引：32

作者：

CASPI, O

POLLIACK, A

KLAR, R

BENYEHUDA, D

机构：

[1] Departments of Internal Medicine, Jerusalem

[2] Gastroenterology, Hadassah University Hospital and Hebrew University Hadassah Medical School, Jerusalem

[3] Haematology, Hadassah University Hospital and Hebrew University Hadassah Medical School, Jerusalem

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 17卷 / 3-4期

关键词：

CROHNS DISEASE; ULCERATIVE COLITIS; LEUKEMIA;

D O I：

10.3109/10428199509056830

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammatory bowel diseases, (IBD) including Crohn's disease and ulcerative colitis, are chronic systemic disorders associated with intestinal and other systemic features. Common hematological manifestations of IBD include: anemia, hypercoagulable state, leukocytosis and thrombocytosis. Recently it has been recognized that lymphoma and leukemia can also be associated with both Crohn's disease and ulcerative colitis. Careful review of the literature reveals more than 30 cases of leukemia reported in patients with IBD. Epidemiological data show that this association is statistically significant (relative risk of 5.3; p < 0.01; 95% confidence interval). This review attempts to characterize the clinical features of this association. The etiology of leukemia in these cases seems to be multifactorial and may involve: genetic susceptibility, environmental factors, immune abnormalities, prior exposure to diagnostic radiation and a variety of therapeutic modalities. No definitive time interval, specific pattern or correlation between the extent of bowel involvement and type of leukemia was found. Treatment of leukemia might affect the activity and severity of the inflammatory bowel disease, but there is very little data relating to this issue. There is some evidence suggesting that bone marrow transplantation performed for leukemia may induce remission of both diseases. Further investigation is still required in the future in order to establish a definite relationship between these two disorders.

引用

页码：255 / 262

页数：8

共 45 条

[21]

Pecorari P., Ulcerative colitis in hairy cell leukemia. A case report, Recent Prog. Med., 82, 5, pp. 269-271, (1991)

[22]

Greenstein A.J., Mullin G.E., Strauchen J.A., Heimann T., Janowitz H.D., Aufses A.H., Sachar D.B., Lymphoma in inflammatory bowel disease, Cancer, 69, 5, pp. 1119-1123, (1992)

[23]

Eng C., Farraye F.A., Shulman L.N., Peppercorn M.A., Krauss C.M., Connors J.M., Stone R.M., The association between the myelodysplastic syndromes and Crohn's disease, Ann. Int. Med., 117, 8, pp. 661-662, (1992)

[24]

Ekbom A., Helmick C., Zack M., Adami H.O., The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden, Gastroenterol, 100, pp. 350-358, (1991)

[25]

Jayanthi V., Probert C.S., Sher K.S., Mayberry J.F., Current concepts of the etiopathogenesis of inflammatory bowel disease, Am. J. Gastroenterol., 86, 11, pp. 1566-1572, (1991)

[26]

Greenstein A.J., Gennuso R., Sachar D.B., Heimann T., Smith H., Janowitz H.D., Aufses A.H., Extraintestinal cancers in inflammatory bowel disease, Cancer, 56, 12, pp. 2914-2921, (1985)

[27]

Incidence Data., (1975)

[28]

Konstantinova B., Nedkova-Bratanowa N., Chromosomal abberations in patients with ulcerohemorrhagic colitis, Digestion, 2, pp. 329-337, (1969)

[29]

Emerit I., Michelson A.M., Chromosomal breakage in Crohn's disease, Recent advances in Crohn's disease, pp. 225-229, (1981)

[30]

Deusch K., Reich K., Immunological aspects of inflammatory bowel disease, Endoscopy, 24, 6, pp. 568-577, (1992)

← 1 2 3 4 5 →