A NEW TEMPERATURE-RESPONSIVE AND PH-RESPONSIVE COPOLYMER FOR POSSIBLE USE IN PROTEIN CONJUGATION

被引：104

作者：

CHEN, GH

HOFFMAN, AS

机构：

[1] Center for Bioengineering, University of Washington, Seattle, Washington, 98 195

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 1995年 / 196卷 / 04期

关键词：

D O I：

10.1002/macp.1995.021960424

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The temperature- and pH-sensitive copolymers of N-isopropylacrylamide (NIPAAm) with 4-pentenoic acid (PAc) were synthesized and the monomer reactivity ratios were estimated. The effects of polymer composition, pH and ionic strength of the aqueous solution on the lower critical solution temperature (LCST) of the copolymers were investigated. It was found that the LCSTs of these unusual copolymers can be either lowered or raised compared to the LCST of poly(N-isopropylacrylamide) by changing the pH.

引用

页码：1251 / 1259

页数：9

共 26 条

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