ESTABLISHMENT OF A NEW HUMAN PANCREATIC ADENOCARCINOMA CELL-LINE, MDAPANC-3

被引：35

作者：

FRAZIER, ML

PATHAK, S

WANG, ZW

CLEARY, K

SINGLETARY, SE

OLIVE, M

MACKAY, B

STECK, PA

LEVIN, B

机构：

[1] Departments of Medical Oncology University of Texas, M. D. Anderson Cancer Center, Houston, TX

[2] Departments of Cell Biology, University of Texas, M. D. Anderson Cancer Center, Houston, TX

[3] Departments of Pathology, University of Texas, M. D. Anderson Cancer Center, Houston, TX

[4] Departments of General Surgery, University of Texas, M. D. Anderson Cancer Center, Houston, TX

[5] Departments of Neuro-oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX

来源：

PANCREAS | 1990年 / 5卷 / 01期

关键词：

Cell line; Cholecystokinin; Pancreatic adenocarcinoma;

D O I：

10.1097/00006676-199001000-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A new cell line was established from a liver metastasis of a human pancreatic adenocarcinoma. The cell line, MDAPanc-3, which arose from a moderately differentiated adenocarcinoma, produces carbonic anhydrase II mRNA, but no detectable levels of insulin or alpha amylase mRNA. The stem line chromosome number was determined to be 43, with six marker chromosomes. Growth of MDAPanc-3 is stimulated by cholecystokinin (CCK) fragment 26-33. The cell line will be useful in further studies on the mechanism(s) by which CCK stimulates growth of certain human pancreatic adenocarcinomas and normal human pancreatic exocrine tissue. © 1990 Raven Press, Ltd., New York.

引用

页码：8 / 16

页数：9

共 21 条

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