CEREBRAL AMYLOID ANGIOPATHY AND GRANULOMATOUS-ANGIITIS - IMMUNOHISTOCHEMICAL STUDY USING ANTIBODIES TO THE ALZHEIMER-A4 PEPTIDE

被引：41

作者：

GRAY, F

VINTERS, HV

LENOAN, H

SALAMA, J

DELAPORTE, P

POIRIER, J

机构：

[1] HOP HENRI MONDOR,DEPT PATHOL NEUROPATHOL,F-94010 CRETEIL,FRANCE

[2] UNIV PARIS 12,FAC MED CRETEIL,DEPT NEUROSCI MED,PARIS,FRANCE

[3] HOP AVICENNE,SERV NEUROL,BOBIGNY,FRANCE

[4] UNIV CALIF LOS ANGELES,MED CTR,DEPT PATHOL NEUROPATHOL,LOS ANGELES,CA 90024

[5] HOP HENRI MONDOR,DEPT PATHOL NEUROPATHOL,F-94010 CRETEIL,FRANCE

来源：

HUMAN PATHOLOGY | 1990年 / 21卷 / 12期

关键词：

CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL GRANULOMATOUS ANGIITIS; ALZHEIMER A4-PEPTIDE;

D O I：

10.1016/S0046-8177(06)80045-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neuropathologic study of an 82-year-old male who died from massive cerebral hemorrhage showed extensive amyloid angiopathy, with morphologic and immunohistochemical characteristics similar to those observed in Alzheimer's disease, associated with granulomatous angiitis, including the presence of numerous giant cells. Some of the giant cells contained, in their cytoplasm, congophilic material immunoreactive for the Alzheimer A4 peptide, supporting the hypothesis that the granulomatous angiitis may, in part, represent a foreign body reaction to A4 amyloid deposition. © 1990 W.B. Saunders Company. All rights reserved.

引用

页码：1290 / 1293

页数：4

共 16 条

[1] CEREBRAL AMYLOID ANGIOPATHY PRESENTING AS A MASS LESION [J].