THE CDNA CLONING AND IMMUNOLOGICAL CHARACTERIZATION OF HAMSTER P53

被引：29

作者：

LEGROS, Y

MCINTYRE, P

SOUSSI, T

机构：

[1] INSERM,U301,INST GENET MOLEC,27 RUE J DODU,F-75010 PARIS,FRANCE

[2] SANDOZ INST MED RES,LONDON WC1E 6BN,ENGLAND

[3] ECOLE NORM SUPER,GENET MOLEC LAB,F-75230 PARIS,FRANCE

来源：

GENE | 1992年 / 112卷 / 02期

关键词：

RECOMBINANT DNA; TUMOR-SUPPRESSING GENE; DNA SEQUENCING; MONOCLONAL ANTIBODIES;

D O I：

10.1016/0378-1119(92)90384-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have cloned and sequenced the p53-encoding cDNA of Syrian hamster. The encoded product is 78% and 75% homologous to human and mouse p53, respectively. Immunoprecipitations of the cDNA-encoded protein by monoclonal antibodies specific for mammalian p53 confirmed the identity of protein.

引用

收藏

页码：247 / 250

页数：4

相关论文

共 14 条

[1] ISOLATION OF HUMAN-P53-SPECIFIC MONOCLONAL-ANTIBODIES AND THEIR USE IN THE STUDIES OF HUMAN P53 EXPRESSION [J].

BANKS, L ;

MATLASHEWSKI, G ;

CRAWFORD, L .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 159 (03) :529-534

[2] RAINBOW-TROUT P53 - CDNA CLONING AND BIOCHEMICAL-CHARACTERIZATION [J].

DEFROMENTEL, CC ;

PAKDEL, F ;

CHAPUS, A ;

BANEY, C ;

MAY, P ;

SOUSSI, T .

GENE, 1992, 112 (02) :241-245

[3] P53 TRANSFORMATION-RELATED PROTEIN - DETECTION BY MONOCLONAL-ANTIBODY IN MOUSE AND HUMAN-CELLS [J].

DIPPOLD, WG ;

JAY, G ;

DELEO, AB ;

KHOURY, G ;

OLD, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (03) :1695-1699

[4] ACTIVATING MUTATIONS FOR TRANSFORMATION BY P53 PRODUCE A GENE-PRODUCT THAT FORMS AN HSC70-P53 COMPLEX WITH AN ALTERED HALF-LIFE [J].

FINLAY, CA ;

HINDS, PW ;

TAN, TH ;

ELIYAHU, D ;

OREN, M ;

LEVINE, AJ .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (02) :531-539

[5]

GUILOTTO E, 1987, CELL, V48, P837

[6] MONOCLONAL-ANTIBODIES AGAINST SIMIAN VIRUS-40 T-ANTIGENS - EVIDENCE FOR DISTINCT SUBCLASSES OF LARGE T-ANTIGEN AND FOR SIMILARITIES AMONG NON-VIRAL T-ANTIGENS [J].

GURNEY, EG ;

HARRISON, RO ;

FENNO, J .

JOURNAL OF VIROLOGY, 1980, 34 (03) :752-763

[7] CLONING AND EXPRESSION ANALYSIS OF FULL LENGTH MOUSE CDNA SEQUENCES ENCODING THE TRANSFORMATION ASSOCIATED PROTEIN P53 [J].

JENKINS, JR ;

RUDGE, K ;

REDMOND, S ;

WADEEVANS, A .

NUCLEIC ACIDS RESEARCH, 1984, 12 (14) :5609-5626

[8] P53 - ONCOGENE OR ANTI-ONCOGENE [J].

LANE, DP ;

BENCHIMOL, S .

GENES & DEVELOPMENT, 1990, 4 (01) :1-8

[9] TUMOR SUPPRESSOR GENES [J].

LEVINE, AJ .

BIOESSAYS, 1990, 12 (02) :60-66

[10] MUTATIONS IN THE P53 GENE OCCUR IN DIVERSE HUMAN-TUMOR TYPES [J].

NIGRO, JM ;

BAKER, SJ ;

PREISINGER, AC ;

JESSUP, JM ;

HOSTETTER, R ;

CLEARY, K ;

BIGNER, SH ;

DAVIDSON, N ;

BAYLIN, S ;

DEVILEE, P ;

GLOVER, T ;

COLLINS, FS ;

WESTON, A ;

MODALI, R ;

HARRIS, CC ;

VOGELSTEIN, B .

NATURE, 1989, 342 (6250) :705-708