LOCAL SEQUENCE DEPENDENCE OF RATE OF BASE REPLACEMENT IN MAMMALS

被引：10

作者：

BAINS, W

机构：

[1] PA Consulting Group, Cambridge Laboratory, Melbourn, Royston,

来源：

MUTATION RESEARCH | 1992年 / 267卷 / 01期

关键词：

BASE REPLACEMENT IN MAMMALS; LOCAL SEQUENCE DEPENDENCE; PSEUDOGENES;

D O I：

10.1016/0027-5107(92)90109-F

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

I have analysed the local sequence context of base replacement changes in 78 processed pseudogenes. Transversions occur more often than transitions in a ratio of 3.37 to 1, and G:C is replaced 1.4 times more frequently than A:T. In addition, the bases to the 5' and 3' of the mutating base also influence the rate at which bases change, purine:pyrimidine and pyrimidine:purine pairs changing 1.2 times as fast as purine: purine and pyrimidine:pyrimidine pairs. I discuss implications of this for the mechanism of DNA polymerization in mammals.

引用

页码：43 / 54

页数：12

共 73 条

[31]

KUNKEL TA, 1988, J BIOL CHEM, V263, P4450

[32]

KUNKEL TA, 1979, J BIOL CHEM, V254, P5718

[33] RAT RIBOSOMAL-PROTEIN L35A MULTIGENE FAMILY - MOLECULAR-STRUCTURE AND CHARACTERIZATION OF 3 L35A-RELATED PSEUDOGENES [J].