THE ACTIVE-ROLE OF BETA-GAMMA IN SIGNAL-TRANSDUCTION

被引：113

作者：

STERNWEIS, PC

机构：

[1] Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9041

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0955-0674(94)90136-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric C proteins and the consequences thereof. While prominence was originally given to the a-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have emerged in the past year. Recent experiments highlight the versatility of beta gamma-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.

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页码：198 / 203

页数：6

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