DIVERSITY AMONG DRW13 DQW7 HAPLOTYPES AS REVEALED BY SEROLOGY DW TYPING AND RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM

被引：4

作者：

GEBUHRER, L ^{[1
]}

FREIDEL, AC ^{[1
]}

LAMBERT, J ^{[1
]}

LABONNE, MP ^{[1
]}

FARRE, A ^{[1
]}

BETUEL, H ^{[1
]}

机构：

[1] BLOOD TRANFUS CTR,HISTOCOMPATIBIL LAB,1-3 RUE VERCORS,F-69007 LYONS,FRANCE

来源：

HUMAN IMMUNOLOGY | 1991年 / 30卷 / 02期

关键词：

D O I：

10.1016/0198-8859(91)90075-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA-DRw13 is in linkage disequilibrium with DQw6; an unusual association, DRw13 DQw7, is found in 2% of our Caucasoid population. Investigation of genotyped individuals and of families by two allosera and by Dw typing revealed two subtypes: one recognized by homozygous typing cell HAG and by two allosera, the other subtype remained unreactive with both reagents. Analysis of DNA fragments with DNA probes indicated that the HAG-negative subset had DNA fragments in common with DRw6 while the HAG-positive subset shared DNA fragments with DR5. However, all DRw13 DQw7 cells are Dw24 as seen by hybridization with DRB probe.

引用

页码：85 / 90

页数：6