STATISTICAL-ANALYSIS OF DOSE-RESPONSE CURVES IN EXTRACELLULAR ELECTROPHYSIOLOGICAL STUDIES OF SINGLE NEURONS

被引：55

作者：

PITTS, DK ^{[1
]}

KELLAND, MD ^{[1
]}

SHEN, RY ^{[1
]}

FREEMAN, AS ^{[1
]}

CHIODO, LA ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,CELLULAR & CLIN NEUROBIOL PROGRAM,DETROIT,MI 48201

来源：

SYNAPSE | 1990年 / 5卷 / 04期

关键词：

ANCOVA; ANOVA; Dopamine neurons; Locus coeruleus;

D O I：

10.1002/syn.890050405

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The application of polynomial regression and the analysis of covariance (ANCOVA) to dose‐response (DR) data derived from extracellular electrophysiological studies of midbrain dopamine neurons and noradrenergic locus coeruleus neurons in vivo is demonstrated and discussed. Third‐order polyomial regression was found to be a better method for estimating ED50 values than probit analysis or linear regression. ANCOVA provides a more powerful statistical method than ANOVA for detecting significant differences in ED50 values or DR curves when a confounding variable such as basal discharge rate is present. The methods of analysis presented herein should be useful in the analysis of other types of neurons in electrophysiol studies. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：281 / 293

页数：13

共 62 条

[11]

BRASZKO JJ, 1981, J PHARMACOL EXP THER, V216, P289

[12]

BUNNEY BS, 1983, ACTA PHARM SUECICA S, V1, P138

[13]

BUNNEY BS, 1976, BASAL GANGLIA, P249

[14]

BUNNEY BS, 1979, NEUROBIOLOGY DOPAMIN, P417

[15] IS THE K PERMEABILITY OF THE RESTING MEMBRANE CONTROLLED BY THE EXCITABLE K CHANNEL [J].

CHANG, DC .

BIOPHYSICAL JOURNAL, 1986, 50 (06) :1095-1100

[16] DOPAMINE-CONTAINING NEURONS IN THE MAMMALIAN CENTRAL NERVOUS-SYSTEM - ELECTROPHYSIOLOGY AND PHARMACOLOGY [J].

CHIODO, LA .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1988, 12 (01) :49-91

[17]

CLARK AJ, 1937, HDB EXPT PHARM, V4

[18] ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL CHARACTERIZATION OF IDENTIFIED NIGROSTRIATAL AND MESOACCUMBENS DOPAMINE NEURONS IN THE RAT [J].

CLARK, D ;

CHIODO, LA .

SYNAPSE, 1988, 2 (05) :474-485

[19] AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE ACTIONS OF THE 3-PPP ENANTIOMERS ON THE NIGROSTRIATAL DOPAMINE SYSTEM [J].

CLARK, D ;

ENGBERG, G ;

PILEBLAD, E ;

SVENSSON, TH ;

CARLSSON, A ;

FREEMAN, AS ;

BUNNEY, BS .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1985, 329 (04) :344-354

[20] HOW WE SHOULD MEASURE CHANGE - OR SHOULD WE [J].

CRONBACH, LJ .

PSYCHOLOGICAL BULLETIN, 1970, 74 (01) :68-80

← 1 2 3 4 5 6 7 →