PHOTODYNAMIC THERAPY OF CHEMICALLY-INDUCED AND ULTRAVIOLET-B RADIATION-INDUCED MURINE SKIN PAPILLOMAS BY CHLOROALUMINUM PHTHALOCYANINE TETRASULFONATE

被引:31
作者
AGARWAL, R
ATHAR, M
ELMETS, CA
BICKERS, DR
MUKHTAR, H
机构
[1] DEPT VET AFFAIRS MED CTR, CLEVELAND, OH 44106 USA
[2] CASE WESTERN RESERVE UNIV, UNIV HOSP CLEVELAND, SKIN DIS RES CTR, DEPT DERMATOL, CLEVELAND, OH 44106 USA
关键词
D O I
10.1111/j.1751-1097.1992.tb09600.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Photodynamic therapy (PDT) of cancer combines irradiation of tumors with visible light following selective uptake of the photosensitizer by the tumor cells. Photofrin(R)-II (Pf-II) is the only photosensitizer which is in clinical use in PDT, whereas chloroaluminum phthalocyanine tetrasulfonate (AlPcTS) has also shown promise in preclinical studies. In most such studies, the effectiveness of the photosensitizers has been assessed in implanted tumor model systems rather than in model systems where tumors are allowed to grow in their own connective tissue matrix. In this study the pharmacokinetics, tumor ablation capability and cutaneous photosensitization response of AlPcTS have been assessed in mice bearing chemically and ultraviolet B radiation (UVB)-induced benign skin papillomas. When tumor-bearing animals were injected intraperitoneally with AlPcTS (5 mg/kg body wt), maximum tumor:normal skin ratio of 2.4 was observed at 48 h, at which time the mice were irradiated within the absorption spectrum of the photosensitizer. In tumor ablation studies with SENCAR mice bearing chemically-induced skin tumors, AlPcTS resulted in greater than 80%. ablation in tumor volume at 20 days post-irradiation. In cutaneous photosensitization response, AlPcTS produced only transient effects (no effect after 24 h) in SENCAR mice. Pharmacokinetics data, tumor ablation effects and cutaneous photosensitization response of AlPcTS were comparable in SKH-1 hairless mice beating UVB-induced skin tumors. Our data indicate that AlPcTS produces significant photodynamic effects towards the ablation of murine skin tumors, and that it does not produce prolonged cutaneous photosensitivity.
引用
收藏
页码:43 / 50
页数:8
相关论文
共 55 条
  • [51] PHOTODYNAMIC THERAPY WITH PHTHALOCYANINE SENSITIZATION - QUANTITATIVE STUDIES IN A TRANSPLANTABLE RAT FIBROSARCOMA
    TRALAU, CJ
    MACROBERT, AJ
    COLERIDGESMITH, PD
    BARR, H
    BOWN, SG
    [J]. BRITISH JOURNAL OF CANCER, 1987, 55 (04) : 389 - 395
  • [52] MOUSE SKIN PHOTOSENSITIVITY WITH DIHEMATOPORPHYRIN ETHER (DHE) AND ALUMINUM SULFONATED PHTHALOCYANINE (ALSPC) - A COMPARATIVE-STUDY
    TRALAU, CJ
    YOUNG, AR
    WALKER, NPJ
    VERNON, DI
    MACROBERT, AJ
    BROWN, SB
    BOWN, SG
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1989, 49 (03) : 305 - 312
  • [53] ALUMINUM SULFONATED PHTHALOCYANINE DISTRIBUTION IN RODENT TUMORS OF THE COLON, BRAIN AND PANCREAS
    TRALAU, CJ
    BARR, H
    SANDEMAN, DR
    BARTON, T
    LEWIN, MR
    BOWN, SG
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) : 777 - 781
  • [54] TRALAU CJ, 1990, PHOTODYNAMIC THERAPY, V1, P263