THE EFFECT ON DNA CLEAVAGE POTENCY OF TETHERING A SIMPLE CYCLIC ENEDIYNE TO A NETROPSIN ANALOG

被引：51

作者：

SEMMELHACK, MF ^{[1
]}

GALLAGHER, JJ ^{[1
]}

DING, WD ^{[1
]}

KRISHNAMURTHY, G ^{[1
]}

BABINE, R ^{[1
]}

ELLESTAD, GA ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV MED RES,PEARL RIVER,NY 10965

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 16期

关键词：

D O I：

10.1021/jo00095a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The attachment of a simple 10-membered. monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

引用

页码：4357 / 4359

页数：3

共 32 条

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