A SILICONE PELLET FOR CONTINUOUS COCAINE - COMPARISON WITH CONTINUOUS AMPHETAMINE

被引：17

作者：

LIPTON, J ^{[1
]}

ZEIGLER, S ^{[1
]}

WILKINS, J ^{[1
]}

ELLISON, G ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT PSYCHIAT,LOS ANGELES,CA 90024

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 04期

关键词：

COCAINE; AMPHETAMINE; DRUG REGIMEN; PSYCHOSIS; RATS;

D O I：

10.1016/0091-3057(91)90266-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

An inexpensive silicone pellet is described for the continuous administration of cocaine for up to 5 days. Rats implanted with this pellet show minimal skin irritation and go through distinct behavioral stages, with an initial period of hyperactivity followed by motor stereotypies. Then, at 3-4 days after implantation, a variety of hallucinogen-like ("late-stage") behaviors appear, including limb flicks, sudden startle responses, and repetitive mid-air grasping movements. Compared to continuous d-amphetamine, continuous cocaine induces decreased motor stereotypies but heightened "late-stage" behaviors.

引用

页码：927 / 930

页数：4

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