A SILICONE PELLET FOR CONTINUOUS COCAINE - COMPARISON WITH CONTINUOUS AMPHETAMINE

被引：17

作者：

LIPTON, J ^{[1
]}

ZEIGLER, S ^{[1
]}

WILKINS, J ^{[1
]}

ELLISON, G ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT PSYCHIAT,LOS ANGELES,CA 90024

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 04期

关键词：

COCAINE; AMPHETAMINE; DRUG REGIMEN; PSYCHOSIS; RATS;

D O I：

10.1016/0091-3057(91)90266-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

An inexpensive silicone pellet is described for the continuous administration of cocaine for up to 5 days. Rats implanted with this pellet show minimal skin irritation and go through distinct behavioral stages, with an initial period of hyperactivity followed by motor stereotypies. Then, at 3-4 days after implantation, a variety of hallucinogen-like ("late-stage") behaviors appear, including limb flicks, sudden startle responses, and repetitive mid-air grasping movements. Compared to continuous d-amphetamine, continuous cocaine induces decreased motor stereotypies but heightened "late-stage" behaviors.

引用

页码：927 / 930

页数：4

共 25 条

[11]

HUBERMAN H, 1977, J PHARM, V45, P237

[12] LACK OF LONG-TERM MONOAMINE DEPLETIONS FOLLOWING REPEATED OR CONTINUOUS EXPOSURE TO COCAINE [J].

KLEVEN, MS ;

WOOLVERTON, WL ;

SEIDEN, LS .

BRAIN RESEARCH BULLETIN, 1988, 21 (02) :233-237

[13]

MANSCHRECK TC, 1988, YALE J BIOL MED, V61, P115

[14]

NAYAK PK, 1976, J PHARMACOL EXP THER, V196, P556

[15] ENHANCED STEREOTYPES AFTER REPEATED INJECTIONS BUT NOT CONTINUOUS AMPHETAMINES [J].

NELSON, LR ;

ELLISON, G .

NEUROPHARMACOLOGY, 1978, 17 (12) :1081-1084

[16] FOLLOWING SEVERAL DAYS OF CONTINUOUS ADMINISTRATION D-AMPHETAMINE ACQUIRES HALLUCINOGEN-LIKE PROPERTIES [J].

NIELSEN, EB ;

LEE, TH ;

ELLISON, G .

PSYCHOPHARMACOLOGY, 1980, 68 (02) :197-200

[17]

POST RM, 1975, AM J PSYCHIAT, V132, P225

[18]

POST RM, 1976, BIOL PSYCHIAT, V11, P403

[19] ENHANCED RESPONSIVENESS TO INTRA-VENTRICULAR INFUSION OF AMPHETAMINE FOLLOWING ITS REPEATED SYSTEMIC ADMINISTRATION [J].

REBEC, GV ;

SEGAL, DS .

PSYCHOPHARMACOLOGY, 1979, 62 (01) :101-102

[20] ENDURING CHANGES IN BRAIN AND BEHAVIOR PRODUCED BY CHRONIC AMPHETAMINE ADMINISTRATION - A REVIEW AND EVALUATION OF ANIMAL-MODELS OF AMPHETAMINE PSYCHOSIS [J].

ROBINSON, TE ;

BECKER, JB .

BRAIN RESEARCH REVIEWS, 1986, 11 (02) :157-198

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