INSERTIONAL INACTIVATION OF A GENE WHICH CONTROLS EXPRESSION OF VANCOMYCIN RESISTANCE ON PLASMID PHKK100

被引：12

作者：

HANDWERGER, S ^{[1
]}

DISCOTTO, L ^{[1
]}

THANASSI, J ^{[1
]}

PUCCI, MJ ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO, DIV ANTIINFECT, WALLINGFORD, CT USA

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 92卷 / 01期

关键词：

GENE VANA; VANCOMYCIN RESISTANCE; PLASMID PHKK100;

D O I：

10.1016/0378-1097(92)90533-T

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Expression of inducible high level vancomycin resistance (VM(r)) in enterococci appears to require other plasmid-encoded genes in addition to the previously described structural genes vanA and vanH. Tn917 mutagenesis was used to identify such a region in the Vm(r) plasmid pHKK100. Insertional inactivation of a 693-bp open reading frame upstream from vanH resulted in complete loss of VM(r). This putative 26642-Da protein has been designated VanR.

引用

页码：11 / 14

页数：4

共 18 条

[1] MECHANISM OF RESISTANCE TO VANCOMYCIN IN ENTEROCOCCUS-FAECIUM D366 AND ENTEROCOCCUS-FAECALIS A256
ALOBEID, S
COLLATZ, E
GUTMANN, L
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (02) : 252 - 256
[2] STRUCTURAL RELATIONSHIP BETWEEN THE VANCOMYCIN RESISTANCE PROTEIN VANH AND 2-HYDROXYCARBOXYLIC ACID DEHYDROGENASES
ARTHUR, M
MOLINAS, C
DUTKAMALEN, S
COURVALIN, P
[J]. GENE, 1991, 103 (01) : 133 - 134
[3] CLONING AND HETEROSPECIFIC EXPRESSION OF THE RESISTANCE DETERMINANT-VANA ENCODING HIGH-LEVEL RESISTANCE TO GLYCOPEPTIDES IN ENTEROCOCCUS-FAECIUM BM4147
BRISSONNOEL, A
DUTKAMALEN, S
MOLINAS, C
LECLERCQ, R
COURVALIN, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (05) : 924 - 927
[4] THE VANA GLYCOPEPTIDE RESISTANCE PROTEIN IS RELATED TO D-ALANYL-D-ALANINE LIGASE CELL-WALL BIOSYNTHESIS ENZYMES
DUTKAMALEN, S
MOLINAS, C
ARTHUR, M
COURVALIN, P
[J]. MOLECULAR AND GENERAL GENETICS, 1990, 224 (03): : 364 - 372
[5] PHENOTYPIC AND GENOTYPIC HETEROGENEITY OF GLYCOPEPTIDE RESISTANCE DETERMINANTS IN GRAM-POSITIVE BACTERIA
DUTKAMALEN, S
LECLERCQ, R
COUTANT, V
DUVAL, J
COURVALIN, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (10) : 1875 - 1879
[6] VANCOMYCIN RESISTANCE IS ENCODED ON A PHEROMONE RESPONSE PLASMID IN ENTEROCOCCUS-FAECIUM 228
HANDWERGER, S
PUCCI, MJ
KOLOKATHIS, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (02) : 358 - 360
[7] INDUCTION OF VANCOMYCIN RESISTANCE IN ENTEROCOCCUS-FAECIUM BY INHIBITION OF TRANSGLYCOSYLATION
HANDWERGER, S
KOLOKATHIS, A
[J]. FEMS MICROBIOLOGY LETTERS, 1990, 70 (02) : 167 - 170
[8] CONJUGATION PROTEINS ENCODED BY F SEX FACTOR
KENNEDY, N
BEUTIN, L
ACHTMAN, M
SKURRAY, R
[J]. NATURE, 1977, 270 (5638) : 580 - 585
[9] GENETIC-ANALYSIS OF THE CONJUGAL TRANSFER DETERMINANTS ENCODED BY THE STREPTOCOCCAL BROAD-HOST-RANGE PLASMID PIP501
KRAH, ER
MACRINA, FL
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (11) : 6005 - 6012
[10] PLASMID-MEDIATED RESISTANCE TO VANCOMYCIN AND TEICOPLANIN IN ENTEROCOCCUS-FAECIUM
LECLERCQ, R
DERLOT, E
DUVAL, J
COURVALIN, P
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (03) : 157 - 161

← 1 2 →