EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN GLOTTIC CARCINOMA AND ITS RELATION TO RECURRENCE AFTER RADIOTHERAPY

被引：53

作者：

MIYAGUCHI, M

OLOFSSON, J

HELLQUIST, HB

机构：

[1] UNIV HOSP BERGEN,DEPT OTOLARYNGOL HEAD & NECK SURG,BERGEN,NORWAY

[2] OREBRO MED CTR HOSP,DEPT PATHOL,HEAD & NECK UNIT,OREBRO,SWEDEN

来源：

CLINICAL OTOLARYNGOLOGY | 1991年 / 16卷 / 05期

关键词：

LARYNX; CARCINOMA; EGFR; RADIOTHERAPY;

D O I：

10.1111/j.1365-2273.1991.tb01041.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The expression of EGFR was determined immunohistochemically in two groups of patients with glottic carcinoma, one that recurred after a full course of radiotherapy and one that did not. Using a 4-graded scale (-, +, ++, +++) 80% (12/15) of the recurrent carcinomas had a staining intensity and proportion of stained cells of ++ or more. The same figure for non-recurrent carcinomas was 39% (7/18). The difference is statistically significant (chi-squared with Yates' correction, P < 0.05). The results indicate that an increased expression of EGFR may influence the rate of recurrence of glottic squamous cell carcinoma after radiotherapy.

引用

页码：466 / 469

页数：4

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[11] GENE AMPLIFICATION AND OVEREXPRESSION OF EGF RECEPTOR IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK [J].