INVOLVEMENT OF AN INITIATION-FACTOR AND PROTEIN-PHOSPHORYLATION IN TRANSLATIONAL CONTROL OF GCN4 MESSENGER-RNA

被引：104

作者：

HINNEBUSCH, AG

机构：

[1] Unit on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 04期

关键词：

D O I：

10.1016/0968-0004(90)90215-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of the GCN4 gene of Saccharomyces cerevisiae is one of the best-documented instances of gene-specific translational control in an eukaryote. Upstream open reading frames (uORFs) in GCN4 mRNA modulate the flow of scanning ribosomes to the GCN4 start codon according to the availability of amino acids. Recent results suggest that sequences at the termination codons of the uORFs, a general initiation factor, and a protein kinase all make important contributions to the proper functioning of this interesting translational-control element. © 1990.

引用

页码：148 / 152

页数：5

共 26 条

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[25] MUTATIONS IN THE STRUCTURAL GENES FOR EUKARYOTIC INITIATION-FACTORS 2-ALPHA AND 2-BETA OF SACCHAROMYCES-CEREVISIAE DISRUPT TRANSLATIONAL CONTROL OF GCN4 MESSENGER-RNA
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) : 7515 - 7519
[26] THE POSITIVE REGULATORY FUNCTION OF THE 5'-PROXIMAL OPEN READING FRAMES IN GCN4 MESSENGER-RNA CAN BE MIMICKED BY HETEROLOGOUS, SHORT CODING SEQUENCES
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HINNEBUSCH, AG
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) : 3827 - 3836

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