SYNTHESIS OF CHROMOPHORIC DIPEPTIDES AS SUBSTRATES FOR PAPAIN

被引：2

作者：

DORAN, JD

TONGE, PJ

CAREY, PR

ARYA, P

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT BIOCHEM,CLEVELAND,OH 44106

[2] NATL RES COUNCIL CANADA,STEACIE INST MOLEC SCI,OTTAWA,ON K1A 0R6,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

关键词：

D O I：

10.1016/0960-894X(95)00415-P

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic strategy for obtaining alpha-NH(COOEt)5-MTA-Et (1b), Ala-5-MTA-Et(2), Phe-5-MTA-Et(3) has been described.

引用

页码：2381 / 2384

页数：4

共 10 条

[1] MAPPING ACTIVE SITE OF PAPAIN WITH AID OF PEPTIDE SUBSTRATES AND INHIBITORS
BERGER, A
SCHECHTER, I
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1970, 257 (813) : 249 - +
[2] UNLOCKING THE SECRETS OF ENZYME POWER USING RAMAN-SPECTROSCOPY
CAREY, PR
TONGE, PJ
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (01) : 8 - 13
[3] RESONANCE RAMAN-SPECTROSCOPIC STUDIES OF ENZYME-SUBSTRATE INTERMEDIATES AT 5-K
KIM, MS
CAREY, PR
[J]. JOURNAL OF MOLECULAR STRUCTURE, 1991, 242 : 421 - 431
[4] KINETIC SPECIFICITY IN PAPAIN-CATALYSED HYDROLYSES
LOWE, G
YUTHAVONG, Y
[J]. BIOCHEMICAL JOURNAL, 1971, 124 (01) : 107 - +
[5] ON ACTIVE SITE OF PROTEASES .3. MAPPING ACTIVE SITE OF PAPAIN - SPECIFIC PEPTIDE INHIBITORS OF PAPAIN
SCHECHTER, I
BERGER, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 32 (05) : 898 - +
[6] MECHANISM OF ACTION OF PAPAIN - ARYLDEHYDROALANINES AS SPECTROSCOPIC PROBES OF ACYL ENZYME FORMATION
SMOLARSKY, M
[J]. BIOCHEMISTRY, 1978, 17 (22) : 4606 - 4615
[7] MECHANISM OF PAPAIN CATALYSIS - STUDIES OF ACTIVE-SITE ACYLATION AND DEACYLATION BY THE STOPPED-FLOW TECHNIQUE
SMOLARSKY, M
[J]. BIOCHEMISTRY, 1980, 19 (03) : 478 - 484
[8] RESONANCE RAMAN AND ABSORPTION SPECTROSCOPIC CHARACTERIZATION OF THE CHEMICALLY ENGINEERED ENZYME THIOLSUBTILISIN - COMPARISON WITH A NATURAL THIOLENZYME
TONGE, PJ
CAREY, PR
[J]. JOURNAL OF MOLECULAR LIQUIDS, 1989, 42 : 195 - 212
[9] TONGE PJ, 1990, CHEM SOC REV, V19, P293
[10] WOOD WB, 1981, BIOCH PROBLEMS APPRO, pCH7

← 1 →