TURNING BEHAVIOR INDUCED IN MICE BY A NEUROKININ-A RECEPTOR AGONIST - STEREOSELECTIVE BLOCKADE BY SR-48968, A NONPEPTIDE RECEPTOR ANTAGONIST

被引：28

作者：

PONCELET, M

GUEUDET, C

EMONDSALT, X

BRELIERE, JC

LEFUR, G

SOUBRIE, P

机构：

[1] Sanofi Recherche, Montpellier

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 01期

关键词：

NEUROKININ-A; NK-2; RECEPTOR; DOPAMINERGIC NEURON; STRIATUM; TURNING BEHAVIOR; MOUSE;

D O I：

10.1016/0304-3940(93)90342-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intrastriatal injection of [Nle10]-NKA(4-10), a neurokinin A agonist, (0.05-5 ng/mouse) elicited vigorous contralateral rotations. This behavior was dose-dependently antagonized by SR 48968 (ED50: 0.15 mg/kg i.p.; 0.19 mg/kg p.o.), a selective non-peptide antagonist of NK-2 receptors, but it was not affected by spiroperidol. This suggests that NK-2 receptor stimulation may affect the activity of the striatum without necessarily involving dopaminergic systems.

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页码：40 / 42

页数：3

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