CHARACTERISTICS OF RB-86+ TRANSPORT IN HUMAN ERYTHROCYTES INFECTED WITH PLASMODIUM-FALCIPARUM

被引：16

作者：

KIRK, K ^{[1
]}

ASHWORTH, KJ ^{[1
]}

ELFORD, BC ^{[1
]}

PINCHES, RA ^{[1
]}

ELLORY, JC ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1061卷 / 02期

基金：

英国惠康基金;

关键词：

RB-86; TRANSPORT; INFECTED ERYTHROCYTE; (PLASMODIUM-FALCIPARUM); (HUMAN ERYTHROCYTE);

D O I：

10.1016/0005-2736(91)90296-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human red cells infected in vitro with Plasmodium falciparum showed a significant increase in the rate of both ouabain-sensitive and ouabain-insensitive Rb-86+ influx. The increase in ouabain-insensitive Rb-86+ influx was due, in part, to increased transport via a bumetanide-sensitive system and, in part to transport via a pathway that was absent (or at least inactive) in uninfected cells. The parasite-induced pathway was inhibited by piperine and had a dose response very similar to that of the Gardos channel of uninfected cells but was less sensitive than the Gardos channel to inhibition by quinine.

引用

页码：305 / 308

页数：4

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