THE CRYSTAL-STRUCTURE AND ABSOLUTE-CONFIGURATION OF THE ANTITUMOR PLATINUM COMPLEX TRANS(OH)-PT(OH)2(MALONATO)(1R,2R-CYCLOHEXANEDIAMINE)

被引：12

作者：

GOTO, M

HIROSE, J

NOJI, M

LEE, KI

SAITO, R

KIDANI, Y

机构：

[1] FUKUYAMA UNIV, FAC ENGN, HIGASHIMURA, FUKUYAMA 72902, JAPAN

[2] NAGOYA CITY UNIV, FAC PHARMACEUT SCI, MIZUHO KU, NAGOYA, AICHI 467, JAPAN

[3] SOOKMYUNG WOMENS UNIV, GRAD SCH, DEPT PHARM, SEOUL, SOUTH KOREA

[4] AICHI JUNIOR COLL NURSING, MURIYAMA KU, NAGOYA 467, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期

关键词：

X-RAY DIFFRACTION; ANTITUMOR PLATINUM COMPLEX; ANTITUMOR PLATINUM(IV) COMPLEX ABSOLUTE CONFIGURATION; TRANS(OH)-PT(OH)2(MALONATO)(1R; 2R-CYCLOHEXANEDIAMINE);

D O I：

10.1248/cpb.40.1022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The absolute configuration of the anti-tumor complex trans(OH)-Pt(OH)2(malonato)(IR,2R-cyclohexanediamine) was determined by X-ray anomalous scattering technique. The final unit cell was monoclinic, space group P2(1) with a = 9.142 angstrom, b = 7.788 angstrom, c = 11.946 angstrom, beta = 96.48-degrees, Z = 2. The crystal structure was determined by direct method and difference Fourier synthesis, and refined to R = 0.025 and R(w) = 0.033 based on 2768 independent reflections. The platinum atom has roughly octahedral coordination. The cyclohexane ring has the expected chair configuration, with two amino groups in equatorial positions while the malonato ligand, in contrast, shows a boat conformation for six membered Pt O-C-C-C-O ring.

引用

页码：1022 / 1024

页数：3