EFFECTS OF INTRAVENOUS EPININE ADMINISTRATION ON LEFT-VENTRICULAR SYSTOLIC PERFORMANCE, CORONARY HEMODYNAMICS, AND CIRCULATING CATECHOLAMINES IN PATIENTS WITH HEART-FAILURE

Twenty-six patients with mild to moderate heart failure were studied to determine the effects of epinine infusion (at a rate producing plasma levels similar to those measured after oral administration of 100 mg of the prodrug ibopamine) on left ventricular (LV) function (14 patients), and coronary flow and circulating catecholamines (12 patients). The only significant hemodynamic change at an infusion rate of 0.5-mu-g/kg/min was a 9% (p < 0.05) decrease in systemic vascular resistance (SVR). At an infusion rate of 1-mu-g/kg/min (mean free epinine plasma levels 14.3 +/- 3.7 ng/ml), heart rate (HR), dP/dt(max) (1,405 +/- 255 to 1,490 +/- 320 mm Hg, NS), (dP/dt)/DP40, and the relaxation rate remained unchanged, but the ejection fraction (EF) increased from 32 to 38% (p < 0.001), cardiac output (CO) increased, and SVR decreased by 22% (p < 0.05). In a separate group of 12 patients, epinine infusion at rates of 0.5-1-mu-g/kg/min produced no significant changes in coronary blood flow or myocardial oxygen uptake. At these infusion rates, arterial norepinephrine (NE) and dopamine (DA) levels decreased slightly and arterial and coronary sinus epinephrine increased. In conclusion, epinine, at concentrations similar to those achieved during therapeutic use of ibopamine, had negligible effect on myocardial contractility and relaxation rate in heart failure patients. Cardiac pump function was improved by a decrease in SVR rather than by inotropic stimulation. The data also suggest that these low concentrations of epinine may modulate the sympathetic nervous system, but further studies are needed to determine whether this effect could have clinical significance.