A NOVEL INTRAMOLECULAR HECK REACTION - SYNTHESIS OF A CHOLESTEROL BACCATIN-III HYBRID

被引：32

作者：

MASTERS, JJ ^{[1
]}

JUNG, DK ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

SNYDER, LB ^{[1
]}

PARK, TK ^{[1
]}

ISAACS, RCA ^{[1
]}

ALAIMO, CA ^{[1
]}

YOUNG, WB ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 04期

关键词：

BACCATIN III; HECK REACTIONS; NATURAL PRODUCTS SYNTHESIS; TAXOL;

D O I：

10.1002/anie.199504521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite strong repulsion between the methyl groups, the intramolecular Heck reaction of cyclohexenyl trifluoromethanesulfonate 1, available from 5‐α‐cholestan‐3‐one, proceeds in 50% yield. The product of the Heck reaction can be converted in a few subsequent steps into the cholesterol‐baccatin III hybrid 2. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：452 / 455

页数：4

共 23 条

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