UPTAKE AND DEGRADATION OF MAST-CELL GRANULES BY MOUSE PERITONEAL-MACROPHAGES

被引：57

作者：

LINDAHL, U

PERTOFT, H

SELJELID, R

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT MED & PHYSIOL CHEM,S-75123 UPPSALA,SWEDEN

[2] UNIV TROMSO,INST MED BIOL,N-9001 TROMSO,NORWAY

来源：

BIOCHEMICAL JOURNAL | 1979年 / 182卷 / 01期

关键词：

D O I：

10.1042/bj1820189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

35S-labelled mast-cell granules isolated from mouse mastocytomas were added to mouse macrophages in vitro. The granules were avidly phagocytosed, and subsequently the radioactivity was released to the medium as inorganic [35S]sulphate. After pulse-labelling, a total of about 80% of the cell-associated radioactivity was thus released in the course of 24 h, indicating an extensive breakdown of the sulphated polysaccharides, mainly heparin, present in the granules. The uptake of the mast-cell granules caused pronounced, but reversible spreading of the macrophages.

引用

页码：189 / 193

页数：5